This fonds consists of records created, accumulated and used by Dr. Abram Hoffer during his professional career in Saskatchewan and British Columbia. The records document Hoffer's psychiatric practice, as well as his extensive research on schizophrenia, orthomolecular medicine, and other alternative therapies over a period of approximately fifty years. Personal records are included in the fonds.

The types of records included are correspondence, clinical and patient case files, appointment and personal diaries, subject files, reports, conference and meeting materials, manuscripts, clippings, publications, photographs, sound recordings, and moving images.

The fonds has been arranged into twenty-one series as follows: Personal/Family; Appointment Diaries; General Correspondence; Miscellaneous Correspondence; 'A' Correspondence With Physicians; American Schizophrenia Association/Foundation; Huxley Institute for Biosocial Research; Saskatchewan Schizophrenia Foundation/Canadian Schizophrenia Foundation/International Schizophrenia Foundation; Papers and Manuscripts of A. Hoffer; Subject Files; Psychiatric Research Unit, Saskatchewan Department of Public Health; Reprints, Papers, etc.; Conference, Meetings, Symposia; Clippings and Publications; Audio-Visual Materials; Bibliographic Reference Cards; Clinical Files; Hoffer-Osmond Correspondence; Laity Correspondence; Senior Physicians Society of British Columbia; and Various.